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In the obese group, tirzepatide downregulated genes related to ErbB signaling and glycolysis/gluconeogenesis pathways, while increasing genes related to fatty acid degradation, cortisol synthesis/secretion, and B cell receptor signaling
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In summary, current evidence clearly shows direct cardioprotective effects of GLP-1 and GLP-1RAs in preclinical models of heart failure (Figure 2)
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